The primary agent of all evangelisation efforts is the Holy Spirit. Prayer for one's oikos is therefore of paramount importance. Cell members pray for their oikos daily, they pray for their various intentions and needs and for the opportunity to offer some kind of service or to speak a few words about Jesus that might spark the flame of faith in that person. Further acts of service or words of faith consolidated with regular prayer may help to "fan the flames" in those whose hearts are seeking or perhaps returning to a relationship with God. Your oikos may be quite large so sometimes it is helpful to focus your prayer on two or three specific people you think are open to the work of the Holy Spirit.

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Each time the cell meets its members share briefly how they have tried to evangelise their oikos since the last meeting. This keeps the cell focused on its primary aim of missionary outreach and helps to encourage newer members who may lack confidence. Each meeting has a time of prayer for the members' oikos and intercessory prayers may be offered for the specific intentions of a member of one's oikos. The ultimate aim is to eventually invite someone from our oikos to attend a cell meeting and in this way the cells can grow and multiply over time and through the power of the Holy Spirit.